Induction of hepatic drug metabolizing enzymes in mammals by pesticides: A review

Abstract

The induction of drug metabolizing enzymes in mammals is summarized including both enzymes of the cytochrome P‐450‐dependent microsomal mixed function oxidase system and glutathione S‐transferases. Particular emphasis is placed on the role of pesticides as inducers, the early work being summarized while investigations carried out at North Carolina State University are considered in greater detail. Finally, the possible significance of induction is considered.     

不同氮磷比对多年生水生植物生长特性影响的研究

从氮、磷等植物生长的环境因子出发，研究了高低氮磷营养水平下，不同氮／磷比例的富营养化水体对聚草（Myriophyllum spicatum）、黄花水龙（Jussiaea stipulacea Ohwi）、喜旱莲子草（Alternanthera philoxeroides）生长特性的影响。结果表明，聚草在氮磷比2：1时生物量最大，且生物量在高浓度水平处理明显大于低浓度水平处理（P〈0．01）；黄花水龙在氮磷比10：1～20：1时生物量最大，高低浓度水平处理问生物量无显著性差异；喜旱莲子草在较高氮磷比20：l～40：1时生物量最大，高浓度水平处理时生物量显著性高于低浓度水平处理（P〈0．05）。在低浓度水平处理时，氮为黄花水龙和喜旱莲子草生长的主要限制因子，磷为聚草生长的主要限制因子，且喜早莲子草叶绿素增长期较其他处理提前，而黄花水龙的叶绿素变化在高低营养水平下差异不显著。营养盐水平对聚草茎长和生物量的影响较对黄花水龙和喜旱莲子草的影响明显。     

新中国60年来农业多功能性演变的研究

农业多功能性是近年来国际可持续发展研究与政府闻谈判磋商的热点问题.科学地认识农业多功能性及其演变趋势,对于新时期中国可持续发展战略的制定与实施具有重要意义.鉴于此,该文通过对相关文献和调研资料的整理,从农业的产品生产功能、经济社会功能、生态环境功能、文化休闲功能4个方面.对建国60年来农业多功能性演变的基本趋势进行了初步研究.结果表明,农业产品生产功能在波折中不断提高,而地域之间呈此消彼长现象,总的趋势是农产品生产由南方向北方、由东部向西部转移;农业的经济功能已经大大弱化,但就业和社会保障功能依然极为重要;农业对生态环境的影响,总体来看负面效应要大于正面效应;农业文化传承功能呈全面衰落趋势,但旅游功能则在近年来大为增强.依据这一研究结果,该文进一步探讨了增强我国农业多功能性的政策措施.     

Nonparametric functional data estimation applied to ozone data: prediction and extreme value analysis

The study of extreme values and prediction of ozone data is an important topic of research when dealing with environmental problems. Classical extreme value theory is usually used in air-pollution studies. It consists in fitting a parametric generalised extreme value (GEV) distribution to a data set of extreme values, and using the estimated distribution to compute return levels and other quantities of interest. Here, we propose to estimate these values using nonparametric functional data methods. Functional data analysis is a relatively new statistical methodology that generally deals with data consisting of curves or multi-dimensional variables. In this paper, we use this technique, jointly with nonparametric curve estimation, to provide alternatives to the usual parametric statistical tools. The nonparametric estimators are applied to real samples of maximum ozone values obtained from several monitoring stations belonging to the Automatic Urban and Rural Network (AURN) in the UK. The results show that nonparametric estimators work satisfactorily, outperforming the behaviour of classical parametric estimators. Functional data analysis is also used to predict stratospheric ozone concentrations. We show an application, using the data set of mean monthly ozone concentrations in Arosa, Switzerland, and the results are compared with those obtained by classical time series (ARIMA) analysis.     

紫外分光光度法测定水中对苯二甲酸

紫外分光光度法测定水中对苯二甲酸，具有简便、快速、灵敏、稳定、所用试剂少、选择性好、抗干扰能力强等优点，适合地面水或废水样品的分析，回收率为９４～１１０％     

美洲商陆和籽粒苋对接种伯克氏菌的生理生化响应及其对富集铯的影响

利用盆栽试验研究一株具有重金属耐性的伯克霍尔德氏菌(Burkholderia sp.D54)对美洲商陆和籽粒苋生长及对铯富集的影响.结果表明,接种菌株D54,美洲商陆和籽粒苋总干物重分别比对照处理增加19.8%～33.4%和22.9%～76.6%,美洲商陆和籽粒苋地上部铯含量分别增加4.9%～22.4%和8.1%～19.4%,根中铯含量分别增加6.8%～15.7%和1.1%～10.8%.同时,接种微生物还增加了植物对钾的吸收,提高供试植物的光合反应速率、气孔导度、蒸腾速率和水分利用率,增加铯胁迫条件下植物的抗氧化酶CAT、POD、SOD的活性,降低了MDA的含量.     

虹鳟鱼鳃及肝脏多种CYP1基因表达模式作为生物标志物监测海河水污染状况

以虹鳟鱼为受试生物,以鳃与肝脏多种CYP1基因为生物标志物,在天津境内开展了野外监测实验,分析多种CYP1转录物的表达量变化及它们在不同监测位点的表达模式.实验通过鱼类吊网在特定水域进行野外监测.结果表明,葛沽与海河入海口的6种CYP1基因表达模式很相近,但表达量不同,表明两地的污染成分相近似但水中污染物负荷不同.除了在马厂减河外,CYP1C1/C3在葛沽与入海口受到明显诱导作用,表明马厂减河中存在的污染物种类不同于其它监测位点.因此,利用虹鳟鱼鳃与肝脏中多种CYP1基因表达模式作为生物标志物监测污染物有着很好的前景,不仅可以作为研究环境污染物对水环境和鱼类健康影响的重要手段,还可以为进一步解释化学混合物成分与多种生物反应之间关系提供理论基础.     

峨眉山景区旅游商品的开发与营销模式

通过对旅游商品定义的综述，界定了旅游商品的定义、范围和功能，同时对峨眉山景区旅游商品的开发、需求、购买力等抽取420份问卷作为样本，分析了峨眉山旅游商品的需求现状，并以旅游者需求现状为依据，对峨眉山旅游商品的开发和营销提出了“4P＋4C＋4R”营销策略，以期对其它景区的旅游商品开发和营销具有一定的借鉴意义。     

Design training and aesthetic evaluation: An intergroup comparison

A number of studies have observed differences in the evaluation of visual, aesthetic stimuli between those with and without professional training in art and design. If exposure to design training underlies such differences it follows that evidence of training effects should be observable when comparing subjects at different stages of design training, and not observable when comparing subjects at different stages of non-design training. In addition, this evidence should be consistent with directional predictions. The study reported in this paper investigated this question using a sample of 192 trained and untrained subjects in an evaluative task. Subjects were from two departments (Design and Computer Studies) of the same educational establishment and comprised balanced groups of lecturers, 1st, 2nd and 3rd year undergraduate students. The results obtained demonstrated evaluative differences and patterns of association both within and between the subject groups consistent with a training hypothesis.